Hyaluronidase - (4x500IU)

Innoaesthetics Hyaluronidase 4×500 IU  Professional Filler Correction Enzyme

 

At a Glance ✓  Active ingredient: Hyaluronidase 500 IU per vial ✓  Pack size: 4 vials × 500 IU (2,000 IU total) ✓  Presentation: 5ml bottle with 1ml freeze-dried product per vial ✓  Purpose: Dissolves hyaluronic acid fillers  corrects over-correction, asymmetry, Tyndall effect ✓  Manufacturer: Innoaesthetics (Spain) ✓  For use by: Qualified aesthetic practitioners only ✓  Storage: As per manufacturer guidelines freeze-dried for stability

 

Innoaesthetics Hyaluronidase 4×500 IU is the professional-grade enzyme solution used by aesthetic practitioners to safely and effectively dissolve unwanted hyaluronic acid (HA) filler. Whether managing an over-correction, correcting asymmetry, resolving a Tyndall effect, or responding to a vascular complication, every clinic performing HA filler treatments should have hyaluronidase immediately on hand.

This formulation from Innoaesthetics one of Europe's leading aesthetic pharmaceutical manufacturers  delivers 500 IU of hyaluronidase per vial in a freeze-dried presentation that ensures stability and precision dosing. The 4-vial pack provides sufficient product for multiple corrective sessions or emergency use across different treatment areas.

Also referenced as hyaluronidase 1500 IE in European pharmacopoeial notation the same enzyme, the same mechanism, and the same clinical standard.

What Is Hyaluronidase and How Does It Work?

Hyaluronidase is a naturally occurring enzyme found in the human body. It belongs to the class of enzymes known as glycoside hydrolases proteins that break down glycosaminoglycans, including hyaluronic acid (HA), by cleaving the molecular bonds that give HA its gel-like, volumising properties.

When injected into or adjacent to a hyaluronic acid filler deposit, hyaluronidase hydrolyses the HA chains effectively dissolving the filler. The broken-down HA fragments are then safely metabolised and cleared by the body's lymphatic system, typically within hours to days depending on the volume being dissolved and the concentration of hyaluronidase used.

Innoaesthetics Hyaluronidase 500 IU uses highly purified hyaluronidase in a freeze-dried (lyophilised) format, which is reconstituted with saline solution immediately before use. This approach maximises enzyme stability and ensures consistent potency at the point of treatment.

Key mechanism: Hyaluronidase catalyses the hydrolysis of 1,4-glucuronidic bonds in hyaluronic acid  the same bonds that give HA fillers their structure and longevity. The result is rapid breakdown of the filler matrix, restoring the tissue to its pre-treatment state.

 

Clinical Indications  When to Use Hyaluronidase

     The JCCP, Save Face, and leading aesthetic training bodies across the UK recommend that hyaluronidase is immediately available whenever a practitioner is administering hyaluronic acid filler. Innoaesthetics Hyaluronidase 500 IU is indicated for the following clinical scenarios:

1. Vascular Occlusion Emergency Use

The most critical indication. If HA filler is accidentally injected into or immediately adjacent to a blood vessel, it can cause vascular occlusion compromising blood supply and potentially leading to skin necrosis, visual disturbance, or in extremely rare cases, stroke. Immediate, high-dose hyaluronidase injection is the primary emergency intervention.

⚠  Hyaluronidase for vascular occlusion is a medical emergency protocol. Every practitioner administering HA filler MUST have hyaluronidase on-site and know their emergency protocol before starting any treatment.

 

2. Over-Correction of HA Fillers

Even experienced practitioners occasionally achieve more volume than intended, or client preferences change after treatment. Hyaluronidase allows safe, controlled partial or complete dissolution of HA filler, restoring a more natural appearance. The staged correction protocol two sessions one week apart  is recommended to allow accurate reassessment after initial dissolution.

3. Asymmetry Correction

Where filler has migrated, settled unevenly, or was placed asymmetrically, targeted injection of hyaluronidase to the over-filled side allows correction without the need to dissolve the entire treatment. Precision placement is key experienced practitioners use small volumes to selectively reduce specific deposits.

4. Tyndall Effect

The Tyndall effect is a blue-grey discolouration that occurs when filler is placed too superficially in the skin. It is caused by the optical scattering of light through the HA gel. Hyaluronidase dissolves the superficially placed filler, resolving the discolouration. This is often seen in the tear trough and perioral area where the skin is thin.

5. Lower Eyelid Oedema (Malar Oedema)

Hyaluronic acid placed in or near the tear trough can migrate or attract water, causing lower eyelid swelling and puffiness. Hyaluronidase can safely dissolve the contributing HA, resolving the oedema  particularly when the swelling is persistent or worsening.

6. Hypertrophic Scars and Skin Fibrosis

Hyaluronidase has therapeutic applications beyond filler correction. It can be used to improve the appearance of hypertrophic scars and fibrosis caused by cosmetic cellulite or post-surgical procedures including liposuction, by breaking down the excess glycosaminoglycan matrix that contributes to abnormal tissue architecture.

7. Topical Application

In addition to its injectable use, Innoaesthetics Hyaluronidase is formulated to support topical application. The product can be mixed with two ampoules of saline solution and applied directly to the skin with circular massage until fully absorbed useful for superficial HA deposits or as an adjunct to injection correction in appropriate cases.

Product Specifications

Product name	Innoaesthetics Hyaluronidase
Pack size	4 vials × 500 IU
Concentration	500 IU per 1ml (lyophilised)
Vial volume	5ml bottle containing 1ml freeze-dried product
Total IU per pack	2,000 IU (4 × 500 IU)
Active ingredient	Hyaluronidase
Also known as	Hyaluronidase 1500 IE (European notation), hyaluronidase innoaesthetics
Reconstitution	Mix with saline solution (1ml per vial) immediately before use
Manufacturer	Innoaesthetics, Spain
Application route	Injectable (intradermal/subcutaneous) and topical
Intended users	Qualified aesthetic practitioners only
Regulatory status	CE marked medical device (verify current status with supplier)
Storage	As per manufacturer guidelines lyophilised for extended stability

 

 

What's New in This Formulation

Innoaesthetics has updated their hyaluronidase product with two significant improvements over earlier formulations:

•       New concentration: 500 IU per vial a clinically precise dose that allows practitioners to manage correction in controlled, titratable stages.

•       New presentation: A 5ml bottle containing 1ml of freeze-dried product. The lyophilised (freeze-dried) format significantly extends shelf stability compared to liquid formulations, ensuring the enzyme retains full potency until the point of use.

•       Topical application capability: The formulation supports topical use when mixed with saline expanding its clinical utility beyond injection-only protocols.

 

 

Application Protocol

Injectable Use Corrective Protocol

1.     Reconstitute the lyophilised product with 1ml of sterile saline solution immediately before use

2.     Assess the area to be dissolved  photograph before treatment for comparison

3.     Inject hyaluronidase directly into or adjacent to the HA filler deposit using a fine needle or cannula

4.     Use the minimum effective dose  start conservatively; under-correction is preferable to over-dissolution

5.     Massage the area gently post-injection to distribute the enzyme

6.     Wait a minimum of 2 weeks before reassessing for complete correction

7.     For significant over-corrections or larger deposits, a staged protocol of two sessions one week apart is recommended

8.     Reassess at 2 weeks a further session may be performed if residual filler is present

 

Topical Application Protocol

9.     Mix the contents of one vial with two ampoules of saline solution

10.  Apply to the treatment area with a circular massage motion

11.  Continue until the solution is completely absorbed into the skin

12.  Use as directed by your clinical protocol

 

⚠  Always perform a patch or sensitivity test prior to administration where clinically appropriate. Hyaluronidase can cause hypersensitivity reactions including anaphylaxis in rare cases have emergency anaphylaxis protocols and equipment available. Do not use in patients with known sensitivity to hyaluronidase or bee/wasp venom.

 

 

Why Innoaesthetics Hyaluronidase?

Not all hyaluronidase products are equivalent. Purity, concentration consistency, and formulation stability directly affect clinical outcomes. Innoaesthetics is a Spanish pharmaceutical company with a long track record of producing aesthetics-specific injectable products to pharmaceutical-grade standards. Key reasons practitioners choose this product:

•       Precise 500 IU dosing: Allows staged, controlled correction without over-dissolving critical for delicate areas like lips and tear troughs.

•       Lyophilised stability: Freeze-dried format ensures the enzyme retains full activity until reconstitution, unlike some liquid preparations that degrade over time.

•       4-vial pack: Provides sufficient product for multiple sessions or simultaneous treatment of multiple areas and ensures you are never without stock for an emergency.

•       Dual-use formulation: Suitable for both injectable correction and topical application protocols.

•       European pharmaceutical standards: Manufactured in Spain to rigorous quality control standards by an established aesthetics-specialist laboratory.

 

 

Hyaluronidase 500 IU vs. Other Concentrations What You Need to Know

Hyaluronidase is available in various concentrations most commonly 150 IU, 500 IU, and 1500 IU (also written as 1500 IE in European notation). Understanding the difference matters for clinical practice:

Concentration	Typical Use Case
150 IU	Lower-dose applications; some topical protocols; not always sufficient for emergency vascular occlusion
500 IU (this product)	Standard corrective use over-correction, asymmetry, Tyndall effect; staged correction protocols
1500 IU / 1500 IE	Higher-volume dissolution; vascular occlusion emergencies; large deposits requiring rapid clearance

 

The 500 IU concentration of this Innoaesthetics product strikes the right balance for most corrective indications sufficient for effective dissolution while allowing the practitioner to titrate carefully. For vascular emergencies, multiple vials can be used rapidly to achieve the higher doses required.

Note on European notation: '1500 IE' (Internationale Einheiten) is the German/European equivalent of '1500 IU' (International Units). The enzyme, mechanism, and clinical effect are identical only the labelling convention differs by country.

 

 

Frequently Asked Questions

What is Innoaesthetics Hyaluronidase used for?

Innoaesthetics Hyaluronidase 500 IU is used by aesthetic practitioners to dissolve hyaluronic acid filler. Its primary indications are correcting over-correction, asymmetry, and Tyndall effect from HA filler treatments, managing vascular occlusion emergencies, and treating lower eyelid oedema, hypertrophic scars, and skin fibrosis.

How does hyaluronidase dissolve filler?

Hyaluronidase is an enzyme that hydrolyses the molecular bonds within hyaluronic acid chains, breaking down the HA gel matrix. When injected adjacent to an HA filler deposit, it rapidly degrades the filler, which is then cleared by the body's lymphatic system. The process begins within minutes and visible dissolution is typically apparent within hours.

How many units of hyaluronidase are needed to dissolve filler?

The required dose varies depending on the area, the amount and type of filler being dissolved, and the specific protocol being followed. For minor corrections, 75–150 IU may be sufficient. For larger deposits or vascular emergencies, 300–1500 IU or more may be needed. The 500 IU per vial concentration of this product allows precise, staged dosing across most corrective indications.

What is the difference between hyaluronidase 500 IU and 1500 IE?

These refer to the same enzyme measured in the same unit. 'IU' (International Units) and 'IE' (Internationale Einheiten) are simply the English and German/European abbreviations for the same measurement. A product labelled as 1500 IE contains exactly three times the hyaluronidase of a 500 IU product.

How quickly does hyaluronidase work on filler?

Hyaluronidase begins working immediately on contact with hyaluronic acid. For most corrective cases, visible softening of the treated area occurs within 24–48 hours. Full assessment of dissolution should be made at 2 weeks post-treatment, as swelling from the injection itself can temporarily obscure the final result.

Can hyaluronidase be used topically?

Yes Innoaesthetics Hyaluronidase is formulated to support topical use. When mixed with two ampoules of saline solution and applied with circular massage, it can be used on superficial HA deposits. This formulation's dual injectable and topical capability makes it versatile for a range of clinical applications.

Is hyaluronidase safe?

Hyaluronidase has a well-established safety profile when used by qualified practitioners. The most significant risk is hypersensitivity reaction, which occurs in rare cases and may range from local urticaria to anaphylaxis. Practitioners should always have emergency anaphylaxis protocols in place. It is contraindicated in patients with known hyaluronidase sensitivity or bee/wasp venom allergy.

Does hyaluronidase dissolve the body's natural hyaluronic acid?

Yes hyaluronidase does not distinguish between injected filler HA and the body's naturally occurring HA. This is why precision injection technique is important: the enzyme should be placed as close to the unwanted filler deposit as possible to minimise unnecessary dissolution of surrounding tissue HA. Natural HA is replenished by the body over time.

 

Professional Compliance & Safety Notes

⚠  This product is for use by qualified aesthetic practitioners only. It is not available for consumer purchase. Always maintain hyaluronidase on-site when administering any hyaluronic acid filler treatment, in line with JCCP and Save Face guidance.

 

Key Safety Requirements for Practitioners ✓  Have hyaluronidase immediately available at all HA filler treatment sessions ✓  Know your vascular occlusion emergency protocol before starting treatment ✓  Perform sensitivity testing where clinically indicated ✓  Have anaphylaxis emergency equipment and protocols in place ✓  Use within shelf life of reconstituted product use immediately once mixed ✓  Reconstitute with sterile saline only ✓  Store as per manufacturer guidelines  lyophilised product for maximum stability ✓  Verify your regulatory obligations for stocking and using hyaluronidase in your region

 

 

Related Products

Practitioners sourcing Innoaesthetics Hyaluronidase may also require:

•       Hyaluronic acid dermal fillers (lips, cheeks, tear troughs, jawline)

•       Cannulas and fine gauge needles for filler and correction injections

•       Topical numbing creams (EMLA, LMX4) for pre-treatment anaesthesia

•       Sterile saline solution for hyaluronidase reconstitution

•       Anaphylaxis emergency kits

•       Skin boosters (Profhilo, Restylane Skinboosters, Juvederm Volite)

•       Mesotherapy kits and cocktails

 

Order Innoaesthetics Hyaluronidase 4×500 IU Available exclusively for qualified aesthetic practitioners. Fast UK delivery. Trusted by clinics nationwide. →  Buy Now at Gofillerss.com

 

⚠  This product description is intended for professional aesthetic practitioners only. Hyaluronidase is a prescription-only medicine in some jurisdictions  verify your local regulatory requirements before purchase and use. Always follow manufacturer guidelines for reconstitution, dosing, and storage.